Yes. Zoho CRM allows you to set permission for modules, records, layouts, and fields to determine whether users from a particular role or department can access the data or not. For example, if you want the sales department to have access to only the Leads, Accounts, Deals, and Contacts modules while the customer support team can only access the Cases and Solutions modules, you can create two profiles, Sales and Support, and give them access to the relevant modules.
To create a profile, navigate to Setup > Security Control > Profiles, click Create New Profile and enter the details.
Once you create the profiles, set the module permission:
You can also use layouts to manage different departments. To limit layout access: